Dementia is the UK's biggest killer, claiming more lives than heart attacks and strokes combined. Despite years of exhaustive research costing millions, science has failed to find a cure or 50 mg lisinopril drug to prevent it.

Last year, data on a new drug - donanemab - suggested it could delay the worsening of symptoms in early Alzheimer's, while a similar drug, lecanemab, was almost as effective.

But serious side-effects - a third of patients on donanemab suffered brain bleeds - and the prohibitive cost of £60,000 for an 18-month course meant neither was approved for the NHS.

Now, though, there are fresh hopes for existing, cheaper and readily available drugs, such as aspirin, statins and even the weight-loss jab Ozempic.

‘Repurposing', as it is known, hit the headlines recently following the results of a seven-year study that found people given Zostavax, a shingles vaccine, were 20 per cent less likely to develop dementia, reported the journal Nature.

Similar results were seen with another shingles vaccine, Shingrix, in research published last year by scientists at Oxford University.

The theory is that by preventing reactivation of the herpes zoster virus - which causes chickenpox in childhood and then remains dormant in the body until it is triggered later in life to resurface as shingles - the vaccines ward off inflammation in the nervous system that heightens the risk of dementia.

At around £200 for a shingles jab, researchers said it could be a cheap and easy way to prevent future dementia cases.




Dementia is the UK's biggest killer, claiming more lives than heart attacks and strokes combined





 ‘Repurposing', as it is known, brings fresh hopes for existing, cheaper and readily available drugs, such as aspirin, statins and even the weight-loss jab Ozempic to ward off dementia

And it is not just readily available vaccines that could help.

Earlier this month, scientists at Hallym University College of Medicine in South Korea found that statins - taken by about eight million people in the UK to cut cholesterol and which cost as little as 4p each - reduced the risk of Alzheimer's by 28 per cent.

High cholesterol has been shown to raise dementia risk, possibly by causing blood vessels to become inflamed, restricting blood flow to the brain.

The researchers tracked more than half a million people and found that those who reduced their harmful cholesterol levels by taking statins were much less likely to develop dementia.

Meanwhile, trials have found that over-the-counter painkillers aspirin and ibuprofen might also help prevent dementia.

A recent study in the Journal of the American Geriatrics Society showed that the drugs reduced the risk by up to 20 per cent.

The researchers suggested that they worked by dampening down inflammation in the body's blood vessels and tissues - but only if the drug was taken regularly for more than two years. However, both of those pills - which are known as non-steroidal anti-inflammatory drugs - increase the risk of stomach ulcers and serious internal bleeding if taken for weeks at a time.

Other researchers are probing whether tablets already used to treat high blood pressure can help.

A 2023 study published in JAMA Network Open found drugs called angiotensin-receptor blockers reduced dementia risk by almost a third. It was suggested it could be from boosting blood flow to the brain or partially destroying harmful deposits in the brain that have been linked to the condition.

Even Ozempic, developed as a diabetes treatment but which has become a hugely popular weight-loss medication, might be a weapon against dementia.



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Last year, researchers at Case Western Reserve University in Ohio found its active ingredient, semaglutide, cut the risk of Alzheimer's in patients with type 2 diabetes by two-thirds - most likely because it improves the way the brain uses insulin to lower blood sugar levels.

This might also explain why a cheap type 2 diabetes drug, metformin, has also been shown to protect against dementia.

Some studies suggest common antibiotics may also help, possibly by reducing inflammation. And there is another, even more unlikely, candidate: Viagra.

A study last year by University College London found the erectile dysfunction treatment reduced the risk of Alzheimer's by up to 44 per cent when taken regularly. Viagra relaxes blood vessels, and studies have shown this improves blood flow in the brain.

‘It's entirely possible the next breakthrough in dementia treatment comes from repurposing an old drug,' says Pat Kehoe, a professor of translational dementia research at Bristol University.

But he warns there's little financial incentive for pharmaceutical companies to fund trials, as most of the drugs are so cheap that profits would be tiny. ‘We could be sitting on potential treatments - the problem is getting the funding to find out what they are.'

Old medicines with a new use?


Aspirin and ibuprofen 

Statins

 Blood pressure pills (such as losartan or valsartan)

 Zostavax (a shingles vaccine)

 Ozempic

 Metformin (used for type 2 diabetes)

Viagra 

Antibiotics 



South KoreaNHSOzempicOxford University